Synthesis of Vanillyl acetamide

Dissolve 5 g of vanillyl amine in 50 mL of saturated sodium bicarbonate solution, in an ice bath, start adding 5 mL of acetic anhydride dropwise with stirring. Stir for 15 minutes and isolate the vanillyl acetamide with 4x 20 mL DCM. Then combine the organic layers and distill the DCM off. Then recrystallize the crude vanillyl acetamide sludge in ethanol.

 

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