Synthesis of Nitroisobutylglycerol (NIBG)

To a reflux apparatus in an ice bath add 2 g of potassium carbonate dissolved in 200 mL of  30% formaldehyde, thereafter slowly add 50 mL of nitromethane, stirring is not needed. After some time, a vigorous reaction takes place, followed by gradual darkening, after the vigorous reaction has stopped, the solution is poured into an evaporation dish and heated at 75°C until the crude product is dry. The crude product is then recrystallized with hot ethanol.

Capture

The vigorous reaction taking place, the yield wasn’t important so no reflux apparatus was used

j

The solution gradually darkening after the vigorous reaction

n

Evaporation in a hot water bath

kk

The crude product

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