Synthesis of Methaqualone hydrochloride

Combine 16 g of isatoic anhydride, 11 g o-toluidine and 250 ml of toluene, reflux for 2h. Add 5 g of acetylacetone dissolved in 6 mL of concentrated hydrochloric acid, continue to reflux for 1h. Distill of 200 mL of the toluene, then evaporate the solution to dryness. Recrystallize in hot methanol.

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