Synthesis of Gramine

To a beaker immersed in an ice bath, 7 mL of acetic acid, 3.7 mL of 35% formaldehyde and 6.1 mL of 40% dimethylamine are added. Then 5 g of indole is added to the solution and stirred until clear, after which stirred for 2 h at room temperature. Subsequently, the solution is poured into a solution prepared from 5 g of NaOH in 150 mL of water. The mixture is filtered, washed 3 times with water and recrystallized from hot acetone.


The solution

The solution after the addition of the indole

Stirring the solution at room temperature

The basic mixture

Filtration of the crude product


The recrystallized product

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