Preparation of Copper ibuprofenate

Add ibuprofen to 90°C hot sodium bicarbonate solution, after which add concentrated copper sulfate, use excess ibuprofen because the sodium bicarbonate will react with the copper sulfate to make copper carbonate. Stop adding copper sulfate until no crystals precipitate anymore.

NaHCO3 + C13H18O2 → NaC13H17O2 + H2O + CO2

 

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