Synthesis of Amphetamine Sulfate

Combine 100 mL of glacial acetic acid and 50 mL of water in 125 mL Erlenmeyer flask. Then dissolve 10 g of P2NP in 100 mL of warm isopropanol. While the P2NP mixture cools down, prepare the amalgam, cut 16 g of thick aluminum foil into 1×1 pieces put them to 200 mL of water and add 100 mg of mercury(II) nitrate, stir for 15 minutes and then wash the foil with 100mL of water 3 times. Then add the foil to the acetic acid and stir for 5 minutes, then slowly add the P2NP solution over 10 minutes, stir for 30 minutes, add a reflux condenser because the solution will start to gently boil. Reflux the solution for 1 h, cool down and slowly add 100 g of sodium hydroxide dissolved in 100 mL of cold water with stirring. Pour the mixture into a separatory funnel and collect the top layer, isolate the remaining amphetamine from the aqueous solution with 2x 40 mL of DCM. Combine 2 mL of sulfuric acid and 10 mL of IPA, add it to the organic extract. Recrystallize from hot water.


Dissolving the P2NP in IPA and making the aluminum amalgam



Combining the chemicals and refluxing for 1h

Addition of the sodium hydroxide solution

Addition of the sulfuric acid IPA solution


Filtration and crude amphetamine sulfate

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