Synthesis of Acetanilide

Pour 100 mL of glacial acetic acid to RBF, then add 100 mL of acetic anhydride, slowly add 100 mL of aniline. Start to reflux at 110Ā°C in an oil bath, with stirring for 2.5h. To a 2 L beaker add 1.5 L of ice water, pour the refluxed solution in with vigorous stirring, stir for 10 minutes, filter. Recrystallize the crude acetanilide in 400 mL water with 30 mL of ethanol, heat the solution until it gets clear. Cool down the solution and then put the solution in a freezer for 3h, filter and wash the product with very cold water. Recrystallize again if needed.

Source

Capture

The solutions in the reflux apparatus

f

Reflux started

frg

Poured the hot mixture to the ice bath, strong stirring needed

n

After stirring the solution has lots of white precipitate

k

The crude product

fdd

Recrystallizing the crude product in hot water-ethanol mixture

kk

All of the crude product dissolved

efw

Filtering after the second recrystallization

ff

The crystals

gtg

Dry and pureĀ acetanilide crystals

Scroll to top