Synthesis of 5-Chlorovanillin

Dissolve 17 g of vanillin in 150 mL of glacial acetic acid, start bubbling dry chlorine slowly through the solution, at room temperature. Reaction mixture warmed, after 15 minutes of chlorine bubbling, some crystals started to form, remove the chlorine bubbler and let the solution stand for 12 h at room temperature. Then move filter, wash the crystals with water and collect the crystals.

 

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