Synthesis of 3,4,5-Trimethoxy-β-nitrostyrene

To a reflux apparatus add 150 mL of acetic acid, 40 mL of nitromethane, 21.21 g of 3,4,5-trimethoxybenzaldehyde and 20 mL of cyclohexylamine. Heat at 95°C for 90 minutes and then cool down to 60°C. Slowly add 325 mL of cold water. Then put the mixture into a freezer to crystallize all of the product out. Filter and wash with cold water. Dry in a desiccator.

Source

02_cyclohexylamine_addition

Addition of the cyclohexylamine

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The solution after reflux

06_beaker_dissolved_nitrostyrene

Addition of the water

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The product crystallized out from the cold solution

08_nitrostyrene_in_buchner

Filtration

10_recrystalized_nitrostyrene

The product

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