Synthesis of 3-Ethoxy-4-hydroxy-5-nitrobenzaldehyde

2.72 g of ethylvanillin is dissolved in 15 mL of AcOH and the beaker is placed in an ice bath. A slow addition of 1.4 mL conc. nitric acid is started with vigorous stirring. The temperature must be kept at 10°C.  After the addition, the mixture is stirred at room temperature for 30 minutes. The mixture is then filtered, washed and recrystallized from a 1:1 solution of AcOH-AcOEt.

The nitration of the reactant

Stirring at room temperature

The crude product

The recrystallized product

Scroll to top