Synthesis of 2-(4-Methoxyphenylamino)-2-thioxoacetamide

To a mixture of 3.69 g of p-anisidine, 1.92 g of sulfur and 4.8 mL of triethylamine in 60 mL of dimethylformamide, a slow addition of 3.08 g of 2-chloroacetamide, whilst keeping the temperature below 35 ° C. The mixture is then agitated for 8 h, poured into 600 mL of cold water and the resulting precipitate is filtered off with suction.


The mixture before the addition

The addition and reflux

Crashing the crude product out

A sample of the crude product

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