Synthesis of 2-(4-Methoxyphenylamino)-2-thioxoacetamide

To a mixture of 3.69 g of p-anisidine, 1.92 g of sulfur and 4.8 mL of triethylamine in 60 mL of dimethylformamide, a slow addition of 3.08 g of 2-chloroacetamide, whilst keeping the temperature below 35 ° C. The mixture is then agitated for 8 h, poured into 600 mL of cold water and the resulting precipitate is filtered off with suction.

Source

The mixture before the addition

The addition and reflux

Crashing the crude product out

A sample of the crude product

Scroll to top