Preparation of Bupropion Hydrochloride from Bupropion

To a beaker immersed in an ice bath, add 20 mL of bupropion and lower the pH of the solution to 3 by an addition of 30% HCl with an equivalent amount of isopropyl alcohol whilst stirring. After the addition, place the beaker in a freezer and wait until all of the bupropion HCl crystallizes out, filter, wash with cold DCM and dry in open air.

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Addition of the solution

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